One of Italy's largest cities, Milan has an edge and an energy to it more often associated with the big cities of North America. Indeed, here the almighty Euro is king. The fashion and finance industries define the city's economic landscape, while world class theatre and other cultural attractions give it character.

The city's most famous landmark is the cathedral known as the Duomo, which was not fully completed until 600 years after construction began. Also not to be missed is the most famous opera house in the world, the elegant and inspiring La Scala. Art fans will kick themselves if they miss out on Leonardo da Vinci's Last Supper, displayed at the Cenacolo Vinciano.

Entertainment options abound, and a show at La Scala is a must. For a night out, try the Brera area, peppered with clubs and bars. Also, football (soccer for Americans) fans will want to catch a game of the elite AC Milan team, which plays at San Siro stadium.

Milan, as a premier tourist, business, and convention destination, often suffers from a shortage of available rooms. For this reason, it is necessary to plan ahead and make reservations well in advance. The one time you're guaranteed a room is August, when the city nearly shuts down as the population decamps for the beach to escape stifling heat.